The effect of Mycobacterium leprae on PHA- and PPD-induced inhibition of leukocyte migration in leprosy patients.

The effect of Mycobacterium /eprae was studied on mitogen, PHA and ant igen, PPO-induced leucocyte migrat ion inhibit ion in 44 leprosy patients and 1 3 healthy controls using the leucocyte migrat ion inh ibi tion test . While M. /eprae decreased the PHA-generated inhibit ion of migrat ion of leucocytes in tuberculoid patients and healthy i ndividuals , i t enhanced the inh ibi tory effect on the leucocyte migration in lepromatous patients . However, a un i form decrease by M. /eprae was observed on PPO-induced leucocyte migrat ion inhibi t ion in both groups of leprosy pat ients and healthy controls .